Gabapentin is used as an adjunctive anticonvulsant for epilepsy and seizure disorders and and as an ‘analgesic’ for neuropathic pain, postherpetic neuralgia (shingles), chronic regional pain syndrome and restless legs syndrome.
Brand names: Neurontin; Horizant; Gabarone; Gralise
It is an analog of GABA (gamma-Aminobutyric acid; an inhibitory neurotransmitter), so enhances GABA release to increase synaptic concentration to inhibit neuron firing. The antihyperalgesic effects of gabapentin may also be mediated by the noradrenergic system from activation of spinal alpha2-adrenergic receptors.
Generally well tolerated with minimal side effects.
It is not metabolized in the body.
- used for restless legs sydrome and chronic regional pain syndrome
- side effect is swelling of the feet (peripheral oedema)
Pfizer labeling information on Neurotonin
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