Effects of neuropharmacological drugs on the transmission of impulses:
Neuropharmacological agents either directly or indirectly affect transmissions of impulses (with exception of anaesthetics).
Drugs may affect:
1) Synthesis of transmitters – increase synthesis, decrease synthesis, modify synthesis
2) Storage of transmitters – increase disruption of storage vesicles less transmitter vailable for relaease
3) Release of transmitters – increase release (eg amphetamines), decrease release
4) Binding to receptor – drug binds to receptor activation, drug binds to receptor increase chance of activation by neurotransmitter, or binds to receptor prevents activation
5) Transmitter termination – blocks transmitter reuptake or inhibits transmitter degradation