Methylprednisolone

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Wikis > Pharmacology > Topical Medicaments > Corticosteroids > Methylprednisolone

Methylprednisolone

Mechanism of action:
Topically corticosteroids produce anti-inflammatory, antipruritic and vasoconstrictor responses by binding with a steroid receptor.

Pharmacokinetics:

Topical indications:
Atopic dermatitis, eczematous dermatitis, nummular eczema, contact dermatitis, seborrhoeic dermatitis, eczematised psoriasis

Contraindications:
Allergy or hypersensitivity
Fungal infections and viral diseases of the skin
Critical limb ischaemia

Precautions:
Not to be used in the eye.
Fertility: no data is avialble.
Pregnancy: (in USA, Category C; Category B3 in Australia); has teratogenic effects in pregnant animals.
Lactation: Not known whether topical corticosteroids are distributed into breast milk (systemic
corticosteroids are distributed into breast milk)

Topical Dosage:

Interactions:
There are many possible drug interactions with corticosteroids, but only tend to rarely occur with the topical preparations with prolonged or over-use.
Carbamazepine, phenytoin and rifampicin all induce hepatic enzymes and can lead to an increased metabolism of triamcinolone.
Use of diuretics may lead to hypokalaemia as they also deplete potassium ion concentration in the blood.
Corticosteroids antagonise the effects of neuromuscular blocking agents (eg vecuronium).

Adverse Effects:
Itching and irritation at the site of application. Local reactions are more likely if used with occlusion.
With prolonged use there is an increased risk for atrophy of the epidermis, subcutaneous tissue and dermal collagen; drying and cracking or tightening of the skin; epidermal thinning; telangiectasia; pupura.
Adverse effects are more likely in groin or face applications as the skin is thinner.
(Adverse effects of systemic corticosteroids)

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Availability: Prescription only