Neuromuscular blocking agents
Can be nondepolarising (act by competing with acetylcholine for binding to nicotinicM receptors muscle relaxation; eg tubocurarine, doxacurium) or depolarising (bind to nicotinicM receptors end plate depolarisation remains bound prevents repolarisation; eg succinylcholine).
Also can be short acting (eg succinylcholine, mivacurium), intermediate acting (eg atracurium) or long acting (eg doxacurium).
Used to produce relaxation of skeletal muscle
Clinical uses:
• muscle relaxants during surgery
• facilitation of mechanical ventilation
• during electroconvulsive therapy
Adverse effects:
• respiratory depression
Succinylcholine:
• depolarising neuromuscular blocker
• short acting
• indicated fro malignant hyperthermia
Botulinum toxin:
• potent toxin that causes botulism
• therapeutically used in the management of long standing muscle spasm
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