Nonsteroidial anti-inflammatory drugs (NSAID’s)
Large group of drugs that inhibits prostaglandin production – wide range available
NSAID’s are weak organic acids that bind to serum proteins (usually albumin).
Main use is minor to moderate pain, fever reduction, anti-inflammatory and antiplatelet aggregation.
Most have ionisation constants (pKa) of 3-5, so in acidic environment of GI tract, they are un-ionised can lead to mucosal damage
Mechanism of action:
Inhibit cyclooxygenase – enzyme that converts arachidonic acid into prostaglandins. Prostaglandins play a role in the development of pain, fever and inflammation.