Nonsteroidial anti-inflammatory drugs (NSAID’s)
Large group of drugs that inhibits prostaglandin production – wide range available
NSAID’s are weak organic acids that bind to serum proteins (usually albumin).
Main use is minor to moderate pain, fever reduction, anti-inflammatory and antiplatelet aggregation.
Most have ionisation constants (pKa) of 3-5, so in acidic environment of GI tract, they are un-ionised can lead to mucosal damage
Mechanism of action:
Inhibit cyclooxygenase – enzyme that converts arachidonic acid into prostaglandins. Prostaglandins play a role in the development of pain, fever and inflammation.
Nonsteroidial anti-inflammatory drugs (NSAID’s):
|Preferential COX-2 Inhibitors|
|Selective COX-2 Inhibitors|
|Nonselective COX-2 Inhibitors|
|Propionic acid derivatives:||Ibuprofen||Naproxen||Ketoprofen||Flurbiprofen|
|Enolic Acid derivatives:||Prioxicam||Tenoxicam|
|Acetic Acid derivatives:||Ketorolac||Indomethacin||Nabumetone|
|Indeneacetic acid derivatives:||Sulindac|
|Analgesic & Antipyretics with a weak anti-inflammatory action|
|Para aminophenol derivatives:||Paracetamol (Acetaminophen)|
|We have not yet got to this page to finish it yet. We will eventually. Please contact us if you have something to contribute to it or sign up for our newsletter or like us on Facebook and Instagram or follow us on Twitter.
Page last updated: