Nonsteroidial anti-inflammatory drugs (NSAID’s)

Wikis > Pharmacology > Nonsteroidial anti-inflammatory drugs (NSAID’s)

Nonsteroidial anti-inflammatory drugs (NSAID’s)

Large group of drugs that inhibits prostaglandin production – wide range available
NSAID’s are weak organic acids that bind to serum proteins (usually albumin).
Main use is minor to moderate pain, fever reduction, anti-inflammatory and antiplatelet aggregation.

Most have ionisation constants (pKa) of 3-5, so in acidic environment of GI tract, they are un-ionised  can lead to mucosal damage

Mechanism of action:
Inhibit cyclooxygenase – enzyme that converts arachidonic acid into prostaglandins. Prostaglandins play a role in the development of pain, fever and inflammation.

Nonsteroidial anti-inflammatory drugs (NSAID’s):

Preferential COX-2 Inhibitors

Selective COX-2 Inhibitors

Nonselective COX-2 Inhibitors
Propionic acid derivatives:IbuprofenNaproxenKetoprofenFlurbiprofen
Enolic Acid derivatives:PrioxicamTenoxicam
Acetic Acid derivatives:KetorolacIndomethacinNabumetone
Pyrazolane derivatives:PhenylbutazoneOxyphenbutazone
Indeneacetic acid derivatives:Sulindac
Fenamate:Mephenamic acid

Analgesic & Antipyretics with a weak anti-inflammatory action
Para aminophenol derivatives:Paracetamol (Acetaminophen)
Benzoxazocine derivatives:Nefopam
Pyrazolone derivatives:PropiphenazoneMetamizol

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