Tamoxifen (ta-mox’i-fen) is a selective estrogen receptor modulator used to prevent receptor positive breast cancer, especially as an adjunctive therapy following surgery.
Mechanism:
Competitively inhibits estrogen binding to its receptor, which is needed for it’s activity in breast cancer cells.
Pharmacokinetics: Bioavailability is almost 100%; mostly binds with albumin; metabolized in liver; elimination half-life is 5–7 days; excretion is mostly via feces and urine.
Side effects:
Hot flashes; night sweats; weight gain; edema; loss of menstrual periods; fatigue; headaches; leg cramps.
Rare risk include: deep vein thrombosis (DVT); strokes; cataracts; endometrial cancer
Brand Names: Nolvadex, Soltamox, Tamifen, Genox, and others
Chemical formula: C26H29NO
External Link:
Nail surgery and Tamoxifen (Podiatry Arena)
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