Colchicine

Colchicine:
• relieves pain from acute attack  useful as a diagnostic aid
• works as anti-inflammatory agent (specific for gout) - interferes with polymorphonuclear leukocyte activity by binding irreversibility to tubulin dimers, preventing assembly into microtubules  interferes with neutrophil chemotaxis. Also interferes with phagocytosis by neutrophils and inhibits pholipase A2  decreased levels of prostaglandins
• has no effect on serum urate concentration or urate metabolism
• readily absorbed orally; excreted in faeces
• adverse effects – gastrointestinal toxicity

Comments are closed.