Colchicine:
• relieves pain from acute attack useful as a diagnostic aid
• works as anti-inflammatory agent (specific for gout) - interferes with polymorphonuclear leukocyte activity by binding irreversibility to tubulin dimers, preventing assembly into microtubules interferes with neutrophil chemotaxis. Also interferes with phagocytosis by neutrophils and inhibits pholipase A2 decreased levels of prostaglandins
• has no effect on serum urate concentration or urate metabolism
• readily absorbed orally; excreted in faeces
• adverse effects – gastrointestinal toxicity
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