Itraconazole

Itraconazole:
• eg Sporanox
• imidazole derivative
• major side effect is hepatitis (<1/800; reversible) • interactions – do not take with astemizole, cisapride; effects decreased with rifampin, H2 blockers; increases effects of felodipine, cyclosporine, digoxin and maybe warfarin and oral hypoglycaemics. • onychomycosis dosage: 200mg bid for 1 week per month for 3 months for toenails • tinea pedis dosage: 200mg bid for 1 week

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