• Levdopa (precursor of dopamine) restores dopamine levels by being converted by enzymes to dopamine
• drug of choice (75% get 50% reduction in symptoms) – full response takes 2-3 months, but after 5 years less effective
• crosses blood-brain by active transport, then taken up into remaining dopaminergic nerve terminal in the striatum converted to dopamine
• administered orally; absorbed rapidly by GI tract; only small amount reaches brain (metabolised by decarboxylase enzymes)
• effectiveness reduced when used with vitamin B6, phenytoin or benzodiazepines; MAO inhibitors increase risk for hypertension.
• contraindications – narrow angle glaucoma;
• adverse effects – nausea and vomiting (especially early), orthostatic hypertension, involuntary movements of limbs and face (dyskinesia), hallucinations and other psychiatric effects (common reason for limiting use).
|We have not yet got to this page to finish it yet. We will eventually. Please contact us if you have something to contribute to it or sign up for our newsletter or like us on Facebook and Instagram or follow us on Twitter.
Page last updated: