• main drug in this class; derived from the deadly nightshade plant; belladonna alkaloid
• competitive blocking at muscarinic receptors – has no direct effect on its own ( have no effect in the absence of acetylcholine)
• prevents receptor being activated by acetylcholine or muscarinic agonist
• can also affect nicotinic receptors at high doses; well absorbed from gut
• effects are opposite to that of muscarinic agonists – increases heart rate; decreases secretion from exocrine glands; relaxation of bronchi; decrease tone of urinary bladder; decreased tone and motility of gastrointestinal tract; dilation of pupil in eye; mild CNS excitation
• used for pre-anaesthetic medication to reduce secretions; bradycardia; peptic ulcers; asthma
• side effects – due to block of muscarinic receptor – eg dry mouth, blurred vision, photophobia, dry eyes, increased intraoccular eye pressure, retention of urine, constipation, anhidrosis, tachycardia, reduced sweating, drowsiness, hallucinations
Find Weird and Wonderful Books at AbeBooks

We have not yet got to this page to finish it yet. We will eventually. Please contact us if you have something to contribute to it or sign up for our newsletter or like us on Facebook and Instagram or follow us on Twitter.

Page last updated: @ 5:47 am

Comments are closed.