Resistance to antibiotics

Wikis > Pharmacology > Antimicrobial Therapy > Resistance to antibiotics

Resistance to antibiotics

Considerable importance as it renders current antimicrobials ineffective.

Organisms can become less susceptible or loose sensitivity to drug over time.

Mechanisms of microbe drug resistance:
• microbes may synthesis enzymes that metabolise the antibiotic (eg increased synthesis of pencillinase)
• microbes do not take up the antibiotic if mechanism of action is intracellular (eg resistance to tetracyclines)
• receptors on surface of microbe undergo changes(s)
• microbes may synthesise compounds to antagonise drug actions

Mechanisms by which resistance is acquired:
• spontaneous mutation (random changes in microbes DNA)
• conjugation

Antibiotic use and development of drug resistant organisms:
If a drug resistant organism is present, antibiotics create the environment in which selection favours that organism.
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