Pharmacokinetics

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Pharmacokinetics

Pharmacokinetics is the study of the movement of drugs, what the body does to the drug – it is concerned with the rate at which drug molecules cross the cell membrane to enter the body – to distribute within it and to leave the body. The pharmacokinetics of a particular drug will determine dosing schedules as drugs must reach a certain level and be able to get to their site of action. A drug is generally a foreign body  the body will try to eliminate it, so the administration and ongoing action of a drug must allow for a constant concentration in the body for it to be effective.

Pharmacokinetic terminology:
Ab Amount in body
AUC Area under the curve
Cl Clearance
Cmax Peak concentration/concentration maximum
Cp Plasma concentration
Cpt Plasma concentration at time t
Cp0 Plasma concentration at time 0
Cpss Plasma concentration at steady state
k the rate constant of equilibrium
LD Loading dose
ln log to the base e
PB Protein binding
ss Steady state
t1/2 half life of elimination
Tmax Time to maximum concentration
Vd Volume of distribution

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