Drug – Receptor Interactions:
Most drugs have their effect via acting through specific protein receptors to do the following:
1) Activate receptors produce a response (agonists)
2) Associate with receptors reduce change of other agents activating receptor (antagonist)
Drugs are initially attracted to receptor via a weak electrostatic charge – if shape of drug is compatible with receptor chemical bonds
Affinity – refers to the strength of the attraction between the drug and its receptor
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