Carbonic anhydrase inhibitors

Wikis > Pharmacology > Drugs acting on the Kidney’s > Diuretics > Carbonic anhydrase inhibitors

Carbonic anhydrase inhibitors:
• eg acetazolamide, dorzolamide
• inhibit action of carbonic anhydrase  decreases availability of hydrogen ions and blocks sodium hydrogen exchange mechanism  increase in urinary excretion of sodium, potassium, bicarbonate and water
• in eye  carbonic anhydrase inhibition reduce production of aqueous humor  decreases intraoccular pressure
• indications – mainly used for glaucoma. Rarely used as diuretic – due to increased risk for metabolic acidosis

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