Propranolol

Propranolol:
• widely used beta-adrenergic blocker – blocks beta1 and beta2 receptors
• effects – cardiac beta1 receptors reduces heart rate, reduced force of ventricular contraction and suppresses impulse conduction through the AV node; kidney beta1 receptors  suppresses secretion of renin; lung beta2 receptors  bronchodilation; blood vessels beta2 receptors  vasoconstriction; skeletal muscle and liver beta2 receptors  inhibition of glycogenolysis
• highly lipid soluble  crosses membranes easily; well absorbed orally; <30% reaches systemic circulation after first pass through liver • mainly used for hypertension, angina pectoris, cardiac dysarthymias • adverse effects – bradycardia; AV heart block; bronchoconstriction; inhibition of glycoeolysis (risk in diabetes)

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