Epinephrine/adrenaline

Epinephrine/adrenaline:
• catecholamine that activates alpha1, alpha2, beta1, beta2 receptors
• used topically, inhalation or injection (broken down by MAO and COMT)
• short half life
• uses – delay absorption of local anaesthetics, control of bleeding, elevate blood pressure, mydriasis during eye procedures, bronchodilation in asthma, anaphylactic shock
• side effects – hypertension; angina pectoris (activation of receptor increases cardiac work and oxygen demand)

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