Fosravuconazole (Nailin) is an oral triazole antifungal agent approved for the treatment of onychomycosis in Japan since 2017. It has a broad and potent antifungal activity. Fosravuconazole is also effective in treating mycetoma.
Fosravuconazole is a prodrug that is converted into ravuconazole and the mechanism of action is considered to be the inhibition of ergosterol biosynthesis.
Brand names: Nailin (Eisai Ltd, Japan)
Chemical formula: C23H20F2N5O5PS
Systematic chemical name: 4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile
External Link:
Fosravuconazole for onychomycosis (Podiatry Arena)
Other anti fungal drugs:
| Antibiotics | Polyenes: | Nystatin | Amphotericin B | Hamycin | |
| Heterocyclic benzofuran: | Griseofulvin | ||||
| Echinocandins: | Caspofungin | Micafungin | Anidulafungin | ||
| Azoles: | Imidazoles: | Topical: | Clotrimazole | Econazole | Miconazole |
| Bifonazole | |||||
| Systemic: | Ketoconazole | ||||
| Triazoles: | Fluconazole | Itraconazole | Voriconazole | Posaconazole | |
| Efinaconazole | Fosravuconazole | ||||
| Morpholines: | Amorolfine | ||||
| Allylamines: | Terbinafine (oral) | Terbinafine (topical) | |||
| Other topical agents: | Tolnaftate | Benzoic acid | Butenafine | Sodium thiosulfate | Quiniodochlor |
| Undecylenic acid | Ciclopirox olamine | Gentian Violet |
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