Structure of peripheral nerves

Wikis > Neurology > Neuroanatomy > Peripheral nervous system > Structure of peripheral nerves

Structure of peripheral nerves:
Peripheral nerves are the cranial and spinal nerves; consist of parallel bundles of nerve fibres surrounded by connective tissue (support nerve fibres, blood and lymph vessels).

Endoneurium:
• delicate loose connective tissue that surrounds individual nerve fibre/axon and the associated Schwann cell
• Type 1 collagen is most common – has some reticular fibres

Perineurium:
• moderately dense connective tissue sheath that surrounds bundles of nerve fibres  divides groups of nerve fibres into fascicles
• lamellated arrangement of flattened cells (up to 15 layers)

Epineurium:
• dense areolar connective tissue that surrounds the nerve trunk
• continuous with, but loosely attached to surrounding connective tissue  allows for mobility of nerve
• more epineurium is usually present when nerves cross joints
• contains fibroblasts and may contain mast cells; fat is also present in varying amounts (may have protective function)

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