Magnesium Metabolism

Magnesium Metabolism:
4th most common cation in body. 60% in bone. Required for DNA, protein and parathyroid hormone synthesis.
Plasma concentration is controlled by dietary intake and renal/intestinal conservation

Hypomagnesaemia:
• decrease in plasma concentration – due to GI losses (eg vomiting, diarrhoea), malnutrition/inadequate intake, renal losses (eg ketoacidosis), renal disorders
• neuromuscular irritability – hyperactive deep tendon reflexes, muscle cramps, muscle fibrillation
• CNS hyperexcitability, cardiac arrhythmia’s

Hypermagnesaemia:
• increase in plasma concentration. Rare – kidney is effective as excretion of excess unless have renal disease

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