Hodgkin’s Disease

Hodgkin’s Disease:
Malignant lymphoma that is pathologically distinct from other lymphoid malignancies.
Affects all ages – bimodal peaks at 25 and 55 yrs; annual incidence of 4/100 000

4 types:
• nodular sclerosis
• lymphocyte predominant
• mixed cellularity
• lymphocyte depletion

Pathognomonic to all types is the Reed-Sternberg cells (bilobed or multilobed nucleus surrounded by clear halo).

Clinical features:
Rubbery lymphadenopathy (usually neck) – usually painless at presentation; 30% have splenomegaly or hepatomegaly or both at diagnosis; systemically may have fever, night sweats, pruritis

Ann Arbor Classification/Clinical Stages:
Stage 1 – Involvement of a single lymph node region (1) or extralymphatic site (1E)
Stage 2 – Involvement of 2 or more lymph node regions (2) or an extralymphatic site and lymph nodes regions on the same side of the diaphragm (2E)
Stage 3 – Involvement of lymph node regions on both sides of the diaphragm with (3E) or without (3) localised extralymphatic involvement or involvement of the spleen (3S) or both (3SE)
Stage 4 –diffuse involvement of one or more extralymphatic tissues
A – No systemic symptoms
B – Weight loss, drenching sweats

Management:
Radiotherapy
Chemotherapy

Prognosis:
90% with stage 1 are cured by radiotherapy

We have not yet got to this page. We will eventually. Please contact us if you have something to contribute to it or sign up for our newsletter or like us on Facebook and Instagram or follow us on Twitter.

Page last updated: Jul 16, 2022 @ 12:59 am

Comments are closed.