Hyperaldosteronism

Hyperaldosteronism:
Clinical syndrome resulting from excess aldosterone secretion by adrenal cortex, independent of the renin-angiotensin system.

Aetiology:
Primary - >50% due to adenoma of adrenal cortex (Conn’s syndrome; Primary aldosteronism)
Secondary - increased production of aldosterone from adrenal cortex – due to increased stimulus.

Clinical features:
Hypokalaemia, metabolic acidosis, hypertension, muscles weakness, excessive thirst, possible paresthesia’s

Management:
Depends on cause
If adenoma  surgical resection
Aldosterone antagonist – spironolactone

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