Clinical syndrome resulting from excess aldosterone secretion by adrenal cortex, independent of the renin-angiotensin system.
Primary - >50% due to adenoma of adrenal cortex (Conn’s syndrome; Primary aldosteronism)
Secondary - increased production of aldosterone from adrenal cortex – due to increased stimulus.
Hypokalaemia, metabolic acidosis, hypertension, muscles weakness, excessive thirst, possible paresthesia’s
Depends on cause
If adenoma surgical resection
Aldosterone antagonist – spironolactone