Pigmentation Disorders

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Pigmentation Disorders

Pigmentation is central to protection of skin from electromagnetic radiation.
Skin colouration is primarily due to amount of melanin in epidermis – but also influenced by carotenoids in epidermis, oxyhaemoglobin in dermal capillaries and deoxyhaemoglobin in dermal venules

Melanin:
• protects against UV radiation
• high molecular weight, chemically inert
• secreted by melanocytes that rest on basal membrane  transfer melanin to surrounding cells
• determines skin, hair and eye pigmentation – main determinant of skin colour

Melanocytes:
• produce melanin

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