Criticisms of Randomized Controlled Trials

http://www.nejm.org/doi/full/10.1056/NEJMms1604593
http://theness.com/neurologicablog/index.php/nejm-article-on-randomized-clinical-trials/
https://www.sciencebasedmedicine.org/whither-the-randomized-controlled-clinical-trial/
Methodolatry: An over-reliance on placebo-controlled trials
http://scienceblogs.com/insolence/2016/06/27/what-next-for-the-randomized-controlled-clinical-trial/

Related Topic:
Criticisms of Evidence Based Medicine