Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management, edited by Steven A. Olson and Farshid Guilak brings together the most up-to-date research on post-traumatic arthritis (PTA) and its management, this book is a comprehensive presentation of the current thinking on all aspects of the mechanisms of joint injury and subsequent development of PTA. Divided into thematic sections, it includes discussions of the incidence and burden of PTA, both in society at large and in the military population specifically; the relevant experimental work on PTA, from basic science to animal models; peri-articular tissue responses to of joint injury and potential mechanisms of PTA; the current clinical assessment and treatment of common joint injuries leading to PTA; and emerging technologies and treatments for PTA, including biomarkers and stem cell therapies. Taken together, it will be an invaluable resource for orthopedic surgeons, rheumatologists and other joint injury researchers and clinicians.
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Table of contents for Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management:
Arthritis That Develops After Joint Injury: Is It Post-Traumatic Arthritis or Post-Traumatic Osteoarthritis?
Post-Traumatic Arthritis: Definitions and Burden of Disease
Arthritis After Joint Injury: The Military Experience
In Vitro Cartilage Explant Injury Models
Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Anterior Cruciate Transection/Disruption Models of Post-Traumatic Arthritis
Closed Joint ACL Disruption Murine Model of PTA
Whole Joint Models of Articular Injury and Articular Fracture
Instability: Dynamic Loading Models
Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
The Response of Cartilage to Injury
The Response of the Subchondral Bone to Injury
Genetic Variability in the Response to Injury
Aging and Post-Traumatic Arthritis
Potential Mechanisms of PTA: Cell Death
Potential Mechanisms of PTOA: Inflammation
Potential Mechanisms of PTA: Oxidative Stress
Potential Mechanism of PTA: Alterations in Joint Loading
Imaging Specific to Cartilage Injury
Outcomes of ACL Injury: The MOON Consortium
Current Treatment and Outcomes of Intra-articular Fractures
Non-arthroplasty Treatments for PTA in the Lower Extremity
Results of Arthroplasty in Post-Traumatic Arthritis
Measurement of Severity of Injury After Articular Fracture and Correlation with Post-Traumatic Arthritis Development
Biomarkers of PTA
Potential Targets for Pharmacologic Therapies for Prevention of PTA
Stem Cell Therapies for Post-Traumatic Arthritis
Unanswered Questions and Future Directions in Post-Traumatic Arthritis
“This unique book brings together the various aspects of the past, present, and potential future study and research of post-traumatic arthritis (PTA) in one place. … The intended audience is those working in the fields of rheumatology, orthopedic surgery, bioengineering, physical therapy, and healthcare policy. … There is no other book that can compare with this one, as it assimilates the knowledge from all the subdisciplines that feed into this important topic that has received too little attention.” (Samuel J. Chmell, Doody’s Book Reviews, October, 2015)
Book Details:
Title: Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management
Author: Steven A. Olson and Farshid Guilak
Publisher: Springer
Published: June 30, 2015
Language: English
Format: Paperback
Pages: 380
ISBN-10: 1489976055
ISBN-13: 978-1489976055
About the Authors of Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management:
Steven A. Olson, MD, Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USA
Farshid Guilak, PhD, Laszlo Ormandy Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USA
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