Selective Serotonin Reuptake Inhibitors (SSRI’s):
• eg fluoxetine (Prozac™), citalopram, fluvoamine, sertaline, paraoxetine
• have high specificity for inhibition of serotonin reuptake into nerve terminals from synaptic clefts – block serotonin transporters (does not block uptake dopamine or norepinephrine; also does not block histamine, cholinergic or alpha1-adrenoreceptors – TCA’s do). Blockage of reuptake occur rapidly, but therapeutic effects develop over a longer period of time.
• indicated for major depression – as effective as TCA’s but with less side effects
• takes several weeks to reach full therapeutic effect
• also indicated for obsessive compulsive disorder
• adverse effects – hypotension; anticholeringic effects; sedation; nausea; insomnia
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