Reserpine

Reserpine:
• depletes norepinephrine from sympathetic neurons by disrupting storage vesicles and suppressing its synthesis  decreased stimulation of adrenergic receptors  reduction in heart rate, reduction in cardiac output, vasodilation ( reduces blood pressure)
• can produce sedation as it depletes serotonin and catecholamines from CNS neurons
• effects similar to the alpha- and beta-adrenergic blockers
• used for hypertension and psychotic stress
• adverse effect – depression; bradycardia; hypotension

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