Paediatric

Paediatric

For the purposes of drug dosing, children over the age of 12 are usually considered as adults

Pharmacokinetic differences:
Absorption:
• gastric acid output is reduced <2 years, otherwise oral absorption similar to adultsDistribution: • total body water and extracellular fluid volume as a percent of total bodyweight decreases with ageDoses: • usually based on milligrams of drug per kilogram of body weight or on surface area expressed as milligrams per square metre

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