Nitrates

Nitrates:
• eg nitroglycerin, erythrityl tetranitrate, glyceryltrinitrate (GIN), amyl nitrite
• fast acting
• indications – acute treatment and prophylaxis of angina pectoris  decreases pain associated with exertion by decreasing oxygen demand
• most decompose to nitric oxide  activates guanylylcyclase  increased levels of cAMP  activation of protein kinase G and phosphorylation of contractile proteins  dilation of systemic veins  decreased preload  decreases oxygen demands on heart (only modest vasodilatory effect on arterioles)
• nitroglycerin comes in several forms – IV, sublingual tablet (highly lipid soluble  crosses membranes easily), sustained release capsule, transdermal ointment and patch, translingual spray
• adverse effects – headaches (can be severe); hypotension (severe if taken with alcohol); reflex tachycardia

Find Weird and Wonderful Books at AbeBooks

We have not yet got to this page to finish it yet. We will eventually. Please contact us if you have something to contribute to it or sign up for our newsletter or like us on Facebook and Instagram or follow us on Twitter.

Page last updated: Oct 2, 2022 @ 3:14 am

Comments are closed.