Structural Gene Abnormalities (some covered elesewhere)
Mutation in genes that affect structured integrity of connective tissues
Autosomal dominant. Disturbance of mesenchyme tissues. Patients are tall with long thin limbs and ligamentous laxity. Feet are longer and narrower. Flatfeet are common.
Autosomal dominant – characterised by hyperextensibility of skin, joint hypermobility, joint dislocation and soft tissue calcification. Increase in elliptic fibres in the skin and a degeneration of the skin collagen- lock up classification