Pediatr Dermatol. 2018 Jul 12. doi: 10.1111/pde.13532. [Epub ahead of print]
Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature.
Yu AM1, Ito S2, Leibson T2, Lavi S3, Fu LW3, Weinstein M4,5, Skotnicki SM5,6.
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Abstract
A 4-year-old boy presented with erythematous vesicular plaques, ulceration, edema, and pruritus on the left foot and ankle 10 days after receiving the tetanus, diphtheria, pertussis, and polio; measles, mumps, rubella, and varicella; and hepatitis A/B vaccines. Biopsy showed eosinophilic infiltrates and flame figures, suggesting Wells syndrome. Patch testing showed a 1+ reaction to neomycin and aluminum hydroxide, with a recall reaction of Wells syndrome of the feet bilaterally. We report a rare case of pediatric Wells syndrome triggered by nonthimerosal vaccine components confirmed by patch testing.
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