Drug induced parkinsonism

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Drug induced parkinsonism:
Dopamine antagonists (eg phenothiazines, metaclopramide); dopamine depletors (eg reserpine)  clinical features of parkinsonism due to decrease in central dopaminergic transmission. Develop clinical features of Parkinsons disease – akinesia is most common, resting tremor is less common. Often appears with 2-4 weeks of drug therapy. After withdrawal, may take months for recovery.

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