Neurotransmitters in ANS

Neurotransmitters in ANS:
• Acetylcholine (released by cholinergic fibres) and norepinephrine (released by adrenergic fibres) are the main neurotransmitters
• acetylcholine is released by all preganglionic axons and all parasympathetic postganglionic axons; most of the postganglionic fibres release norepinephrine
• response to neurotransmitter depends on receptor type

Acetylcholine:
Synthesised from acetyl coenzyme A (acetyl CoA) and choline; acetylcholinesterase terminates its action;

Norepinephrine/noradrenaline:
Synthesised from …; action is mostly terminated by reuptake into the neuron from which it was secreted; can also be inactivated in liver by catechol-o-methyl-transferase (COMT) and monoamine oxidase (MAO).