Production of antibodies:
All substances that are identified by the body as foreign act as an antigen incites an immune response
Production begins with binding of specific antigen to a B cell and an antigen presenting cell (macrophage or dendritic cell) APC processes antigen and binds to specific helper T cell T cell proliferates and differentiates into active T cells and memory T cells active T cells bind with processed antigen on B cells B cells proliferate and differentiate into plasma cells manufacture antibodies. Memory cells wait for next antigen attack.
All processed antigen are presented to T cells in the context of the major histocompatibility complex (MHC) – these are expressed on the surface of all nucleated cells and each person has a unique set of MHC antigens.
Type 1 MHC are receptors for CD8 (links macrophages to suppressor/cytotoxic T cells)
Type 2 MHC are receptors for CD4 (links for attachment of macrophages to helper T cells)