Eosinophilic granuloma
Group of lesions – arise from proliferation of Langerhans type histiocytes. More common <12 years. Usually as a result of metabolic defect in reticuloendothelial system.
Most commonly in skull and femur – usually a solitary lesion with minimal symptoms. May have low grade fever and increased ESR.
X-ray – ‘punched out’ radiolucent lesion with thick margin of reactive bone.
Often resolve spontaneously – 10% need treatment.
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