Disseminated Intravascular Coagulation

Disseminated Intravascular Coagulation (DIC):
Acquired bleeding disorder – pathological activation of coagulation mechanisms  widespread clotting in small vessels with consumption of clotting factors and platelets  bleeding and thrombosis occur simultaneously.

Coagulation can be initiated by a number of mechanisms – infection (eg Escherichia coli, malaria); obstetric (abruptio placentae, retained dead foetus, septic abortion, pre-eclampsia, amniotic fluid embolism); neoplasia (eg lung, pancreas, acute leukaemia)

Clinical features:
Easy bruising; coolness and mottling of limbs renal failure; abnormal bleeding

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