Pernicious anaemia

Wikis > General Medicine > Haematology > Anaemia > Pernicious anaemia

Pernicious anaemia:
Due to malabsorption of B12.
Megaloblastic.
Usually from small bowel disease, gastric resection or genetic malabsorption problem.

Clinical features – weakness, tiredness, dyspnoea, parathesia, painful red tongue, dementia, diarrhoea; GI symptoms; neuropathy

Schilling test of decreased absorption of B12 is positive; RBC indices show increased MCV.

Treatment – parenteral replacement with cyanocobalamin monthly for rest of life.

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