Ulcerative Colitis (UC):
Chronic relapsing inflammatory disorder affecting colonic and rectal mucosa.
Due to genetic predisposition and an inappropriate immune response triggered by a dietary, infectious or environmental agent. Prevalence of 80-85/100 000.
Peak ages of onset – 15 to 30 and 50 to 70.
Clinical features – onset usually gradual; first attack is usually the most severe. Inflammation of rectal mucosa (proctitis) rectal bleeding, mucous discharge, frequent diarrhoea, abdominal pain; symptom free between attacks; usually thin, anaemic
Involvement of foot - peripheral arthritis and enthesitis (enteropathic spondyloarthropathy)
Management – psychosocial support; patient support groups; dietary and nutritional advice; symptomatic drugs (eg antidiarrheal drugs; vitamins; osteoporsis prophylaxis); specific treatment drugs (eg sulfasalazine; corticosteroids; antibiotics); surgical (colectomy)
Increased risk for colorectal cancer.