Accumulation in the extracellular tissues of various insoluble fibrillar proteins that associate into amyloid fibrils  impair normal function. As well as protein, the deposits also include glycosaminoglycan and a glycoprotein and serum amyloid P component (SAP)
Can affect on organ or be systemic – may be subclinical or may have a variety of presentations. Can be primary amyloidosis or associated with multiple myeloma

M2x>F. Median age of diagnosis is 65 years.


Clinical features:
Fatigue; weight loss (can be dramatic); pain (if due to myeloma, pain is due to peripheral neuropathy; purpura; bleeding.
Other symptoms will depend on which organ is involved

Ankle oedema if have congestive heart failure

Amyloid can deposit in synovial and periarticular tissues  noninflammatory arthropathy


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