Serum Sickness

Serum Sickness

Type III hypersensitivity reaction from injection of heterologous or foreign protein.

Occurs 6-21 days after administration of inciting antigen – onset more rapid with subsequent exposures.

Classically  fever, arthralgia, lymphadenopathy, skin eruption.
At injection site  pain, pruritus and erythematous swelling may precede onset.
Often get joint and muscle aches.

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