Serum Sickness
Type III hypersensitivity reaction from injection of heterologous or foreign protein.
Occurs 6-21 days after administration of inciting antigen – onset more rapid with subsequent exposures.
Classically fever, arthralgia, lymphadenopathy, skin eruption.
At injection site pain, pruritus and erythematous swelling may precede onset.
Often get joint and muscle aches.
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