Life threatening severe allergic reaction pruritis, urticaria, angioedema, hypotension, bronchospasm – occur within seconds to minutes of exposure to a specific antigen – Type 1 hypersensitivity reaction.
1 in 5000 exposures to parenteral penicillin or cephalosporin anaphylaxis. Other common antigens that may trigger reaction include foods, additives, stings and bites.
If untreated respiratory and vascular collapse death within minutes to hours.
90% have skin involvement – urticaria, erythema, pruritus.
Upper respiratory tract – nasal congestion, sneezing, cough, tightness
Immediate subcutaneous epinephrine/adrenaline vasodilation and bronchial smooth muscle relaxation; CPR if cardiac arrest; monitor for hypotension and shock