Autoimmune Bullous Diseases

Wikis > Dermatology > Blistering Conditions > Autoimmune Bullous Diseases

Autoimmune Bullous Diseases

Pemphigus Vugaris (PV)

Autoimmune (IgG mediated). Superficial circular erosions with occasional flaccid bullae
Potentially life threatening

Keratinocytes produce proteolytic enzymes  breakdown intercellular cement  blistering

Bullous Pemphigoid (BP)

Autoimmune disease, autoantibodies to hemidesmosomes in basement membrane zone
Chronic blistering disease associated with severe itching

Clinical features:
Predominantly in the elderly
Widespread chronic blisters
Foot sometimes affected

Treatment:
Prednisolone.

Dermatitis Hepetiformis (DH)

Epidermolysis bullosa (EB)

Group of disorders.
Increased tendency for skin to blister.

Comments are closed.