Autoimmune Bullous Diseases

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Autoimmune Bullous Diseases

Pemphigus Vugaris (PV)

Autoimmune (IgG mediated). Superficial circular erosions with occasional flaccid bullae
Potentially life threatening

Keratinocytes produce proteolytic enzymes  breakdown intercellular cement  blistering

Bullous Pemphigoid (BP)

Autoimmune disease, autoantibodies to hemidesmosomes in basement membrane zone
Chronic blistering disease associated with severe itching

Clinical features:
Predominantly in the elderly
Widespread chronic blisters
Foot sometimes affected


Dermatitis Hepetiformis (DH)

Epidermolysis bullosa (EB)

Group of disorders.
Increased tendency for skin to blister.

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