Autoimmune Bullous Diseases
Pemphigus Vugaris (PV)
Autoimmune (IgG mediated). Superficial circular erosions with occasional flaccid bullae
Potentially life threatening
Keratinocytes produce proteolytic enzymes breakdown intercellular cement blistering
Bullous Pemphigoid (BP)
Autoimmune disease, autoantibodies to hemidesmosomes in basement membrane zone
Chronic blistering disease associated with severe itching
Clinical features:
Predominantly in the elderly
Widespread chronic blisters
Foot sometimes affected
Treatment:
Prednisolone.
Dermatitis Hepetiformis (DH)
Epidermolysis bullosa (EB)
Group of disorders.
Increased tendency for skin to blister.
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