This phrase originates from the FOX show House, also known as House, M.D. The series revolves around the unconventional and misanthropic genius, doctor Gregory House, working with younger doctors at the Princeton‑Plainsboro Teaching Hospital (PPTH) in New Jersey, in order to solve difficult health mysteries.
The phrase was coined when the younger doctors were suggesting a case of lupus, when they couldn’t figure out what was wrong with the patient. Because lupus usually takes several years to be diagnosed, Dr. House usually says “It’s not lupus.” or “It’s never lupus.”. That was until the team actually ran into a case, where House had to admit there being an actual case of lupus.
http://knowyourmeme.com/memes/it-s-not-lupus?full=1
https://www.youtube.com/watch?time_continue=104&v=bueW1i9kQao
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