Wikis > Pharmacology > Cytotoxic/antineoplastic drugs and Immunosuppressives/Antihistamines > Cytotoxic/antineoplastic drugs > Methotrexate
Methotrexate (folic acid analog):
• inhibits dihydrofolate reductase (enzyme that converts dihydrofolic acid into tetrahydrofolic acid – this is a necessary step in the activation of folic acid needed for synthesis of DNA, RNA and proteins)
• used in conjunction with leucovorin for some cancers to protect normal cells
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